臧永建，博士，讲师，研究生导师
从事理论与计算生物物理研究，搭建蛋白质及其复合体的三维结构，分析其功能。应用分子动力学模拟蛋
白质结构，确定其精细原子结构以及在不同外界环境下的结构变化与功能特性。具体研究兴趣包括：
1）多尺度理论和计算方法。
2）生物大分子折叠组装与相变。
3）蛋白分子结构与功能模拟研究。
稳态/瞬态结构+演化序列+分子动力学模拟=动态分子模型
联系方式：1628830803@qq.com
教育经历：
（1）2016-09至2023-07 西安交通大学，凝聚态物理，（硕博连读）博士
（2）2012-09至2016-06 云南大学，数理基础科学，学士
工作经历：
2023-10至今，云南师范大学，物理与电子信息学院，讲师
代表性论文：
1. Yongjian Zang, He Wang, Dongxiao Hao, Ying Kang, Jianwen Zhang, Xuhua Li, Lei Zhang, Zhiwei Yang, Shengli Zhang*, p38α kinase auto-activation through is conformational transition induced by Tyr323 phosphorylation, Journal of Chemical Information and Modeling, 62(24), 6639-6648, 2022.
2. Yongjian Zang, He Wang, Ying Kang, Jianwen Zhang, Xuhua Li, Lei Zhang, Zhiwei Yang, Shengli Zhang*, TAB1 binding induced p38α conformation change: an accelerated molecular dynamics simulation study, Physical Chemistry Chemical Physics, 24(17), 10506-10513, 2022.
3. Yongjian Zang, Xuhua Li, Yizhen Zhao, He Wang, Dongxiao Hao, Lei Zhang, Zhiwei Yang, Xiaohui Yuan, Shengli Zhang*, Molecular insights into the binding variance of the SARS-CoV-2 spike with human, cat and dog ACE2 proteins, Physical Chemistry Chemical Physics, 23(24), 13752-13759, 2021.
4. Zhiwei Yang, Yongjian Zang (co-first author), He Wang, Ying Kang, Jianwen Zhang, Xuhua Li, Lei Zhang, Shengli Zhang*, Recognition between CD147 and cyclophilin A deciphered by accelerated molecular dynamics simulations, Physical Chemistry Chemical Physics, 24(31), 18905-18914, 2022.
5. Yongjian Zang*, Yu Ni, Xuhua Li, Zhiwei Yang, Zhaoming Fu, Shengli Zhang, Mechanistic insights into the phosphorylation-regulated a disordered protein interaction module. Journal of Biomolecular Structure & Dynamics, DOI:10.1080/07391102.2025.2460748, 2025.
6. Yongjian Zang, Dongxiao Hao, He Wang, Zhiwei Yang, Hudong Liu, Shengli Zhang*, Structure-based methoxyflavone derivatives with potent inhibitory activity against various influenza neuraminidases, Journal of Biomolecular Structure & Dynamics, 38(15), 4617-4624, 2019.
7. He Wang, Yongjian Zang, Ying Kang, Jianwen Zhang, Lei Zhang, Shengli Zhang*, ETLD: an encoder-transformation layer-decoder architecture for protein contact and mutation effects prediction, Briefings in Bioinformatics, 24(5), bbad290, 2023.
8. Ning Liu, Hongli Xaio, Yongjian Zang, Longji Zhou, Mencius, Jun, Zhiwei Yang, Shu Quan, Xi Chen*, Simultaneous improvement in the thermostability and catalytic activity of epoxidase Lsd18 for the synthesis of lasalocid A, International Journal of Molecular Sciences, 24(23), 16795, 2023.
